Local excision after regrowth in rectal sparing: a review on iterative rectal preservation after neoadjuvant treatment.

ABSTRACT:

Introduction

Rectal-sparing strategies for locally advanced rectal cancer are gaining interest owing to favorable oncological results and reduced impact on functional outcomes. In patients managed with watch-and-wait or local excision after neoadjuvant chemoradiotherapy (nCRT), local regrowth occurs in approximately 15-30% of cases. Total mesorectal excision (TME) is the standard treatment for regrowth; however, local excision (LE) may be considered in selected cases to preserve rectal function. This narrative review evaluates clinical and oncological outcomes of patients undergoing LE for suspected regrowth.

Methods

A narrative review of the literature was conducted using databases and search terms including "rectal cancer," "rectal sparing," and "local regrowth."

Result

SUBMITTER: Picotto S 

PROVIDER: S-EPMC12532730 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature