Comparative virulence study of locally circulating peste des petits ruminants virus (PPRV) strains in indigenous Ethiopian goats.

ABSTRACT:

Background

Peste des Petits Ruminants (PPR) is a highly contagious viral disease affecting small ruminants with considerable socioeconomic impacts in Ethiopia. Despite its importance, comparative virulence of locally circulating PPR virus strains in indigenous goats remains poorly characterized. This study evaluated six distinct PPRV strains (four lineage-IV, two lineage-III) in experimentally infected Ethiopian goats. Twenty-one Central highland breed goats (12-30 months) were randomly allocated into six experimental groups and one control group, with three goats in each group and experimental animals inoculated intranasally (10^4.5 TCID₅₀ per ml). Clinical, serological, molecular, and pathogenesis data were collected.

Results

Five of six strains produc

SUBMITTER: Aklilu F 

PROVIDER: S-EPMC12532835 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature