Multidimensional cognitive deficits in the typical and atypical variants of Alzheimer's disease.

ABSTRACT:

Background

In this two-part investigation, we examined whether Alzheimer's disease (AD) phenotypes are distinct clinical entities or represent positions within a graded multidimensional space.

Methods

First, using a large retrospective dataset of past research participants (n = 413) from memory clinics, we examined the comparative distributions of cognitive performance in people diagnosed with typical amnestic AD (tAD), logopenic variant of primary progressive aphasia (lvPPA), and posterior cortical atrophy (PCA), across a broad range of disease severities. Secondly, a prospective deep phenotyping study of lvPPA (n = 18) compared to typical AD (n = 9) addressed the following questions: (1) Does the multidimensional cognitive pattern of impairment only emerge in advanced lvPP

SUBMITTER: Henderson SK 

PROVIDER: S-EPMC12532852 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature