Subtype-specific divergent roles of calpain-1 and calpain-2 in basal A triple-negative breast cancer.

ABSTRACT:

Background

CAPN-1 and CAPN-2, two ubiquitously expressed calpains, have been implicated in cancer progression, but their distinct roles in breast cancer remain poorly defined. This study aims to define the opposing roles of CAPN-1 and CAPN-2 in breast cancer progression, with a focus on their regulatory impact on cell proliferation. Since these calpains may have different functions in the mammary gland, we aimed to investigate the possible antagonistic roles of CAPN-1 and CAPN-2 in breast cancer progression, focusing on their expression patterns and functional impact on cell proliferation.

Methods and results

We analyzed breast cancer cell lines using immunoblotting and real-time cellular assays, showing that HCC1937 cells exhibit an opposite expression pattern of CAPN-1 and

SUBMITTER: Uner G 

PROVIDER: S-EPMC12532864 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature