Promising anti-cervical cancer efficacy and phytochemical analysis of Vitex doniana Sweet (Verbenaceae) leaf extracts: an in vitro investigation with molecular mechanisms of action.

ABSTRACT:

Background

The exploration of natural sources for novel anticancer agents has garnered significant attention in recent years, driven by the need for effective and safe anticancer medications, considering the escalating global burden of cervical cancer. Vitex doniana Sweet (Verbenaceae), a plant with diverse traditional medicinal uses, especially in Africa, has shown promise in this regard due to its rich phytochemical composition.

Methods

This study investigated the cytotoxic and antiproliferative effects of V. doniana extracts on normal mammalian (Vero-CCL-81) and cervical cancer (HeLa) cells, including cancer-associated gene expression profiles, according to standard procedures. Phytochemical analysis was performed using gas chromatography-mass spectrometry (GC-MS).

Res

SUBMITTER: Moriasi G 

PROVIDER: S-EPMC12532901 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature