Five depressive symptom trajectories in three dimensions are risk factors of cancer: a ten-year follow-up study.

ABSTRACT:

Background

This study's goal was to investigate the long-term association between cancer risk and depression symptom trajectories, highlighting the need for dynamic evaluation of depressive symptoms across time.

Methods

Data from 42,911 participants were drawn from two population-based cohorts: the Health and Retirement Study (HRS) from US and the English Longitudinal Study of Ageing (ELSA). The study period covered HRS Rounds 4-12 (1998-2014) and ELSA Rounds 1-9 (2002-2018), with the first six years as the exposure period and the following ten years as the follow-up. The assessment of depressive symptoms was conducted employing the 8-item CES-D scale, with trajectories constructed over repeated assessments. Cancer diagnoses were determined based on self-reported physician c

SUBMITTER: He KJ 

PROVIDER: S-EPMC12532912 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature