Cholesterol oxidase treatment impairs CXCR4-mediated T cell migration.

ABSTRACT:

Background

Cholesterol, a key component of mammalian cell membranes, modulates the properties of the lipid bilayer and influences the conformational states of membrane receptors, including G protein-coupled receptors (GPCRs). These effects are mediated through direct interactions with specific residues within the transmembrane regions and modulation of the surrounding lipid bilayer. Chemokine receptors, a GPCR sub-family, adopt distinct conformations associated with specific cell functions. For example, CXCL12 triggers receptor clustering, essential for directional cell migration. However, the precise mechanisms by which cholesterol controls the spatial organization of these receptors remain unclear. This study investigated the role of cholesterol in modulating the chemokine recept

SUBMITTER: Gardeta SR 

PROVIDER: S-EPMC12532918 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature