The effect of Dexmedetomidine on remote organ injury in the lung in rats with pancreatic ischemia reperfusion model.

ABSTRACT:

Introduction

Pancreatic ischemia-reperfusion (IR) injury can trigger acute lung injury by causing remote organ involvement. Dexmedetomidine has been reported to exhibit antioxidant and cytoprotective effects in various organs. This study aimed to evaluate the protective effects of dexmedetomidine on lung tissue at the histopathological and biochemical levels in an experimental pancreatic IR model.

Methods

A total of 24 male Wistar-Albino rats were randomly divided into four groups: Sham, Sham + Dexmedetomidine, Ischemia-Reperfusion (IR), and IR + Dexmedetomidine (IR-D). Pancreatic ischemia was induced in the IR and IR-D groups by clamping the inferior splenic and gastroduodenal arteries. In the dexmedetomidine groups, the drug was administered intraperitoneally. Lung tissues

SUBMITTER: Aktepe F 

PROVIDER: S-EPMC12532922 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature