Integrated Microbiome and metabolome analysis reveals Microbial-Metabolic interactions in psoriasis pathogenesis.

ABSTRACT:

Background

Psoriasis is a chronic inflammatory skin disorder with unclear etiology. The roles of skin microbiome and metabolic dysregulation in psoriasis pathogenesis are not yet fully understood.

Methods

We conducted an integrated microbiome and untargeted metabolomic analyses on skin samples from 29 patients with psoriasis and 31 healthy controls. The skin microbiota was characterized using 16 S rRNA gene sequencing, and untargeted metabolomic profiling was performed using LC-MS/MS. Multivariate statistical analyses were used to identify differential microbes and metabolites, followed by correlation analyses to explore microbe-metabolite interactions.

Results

Psoriatic lesions exhibited significantly higher skin microbial alpha diversity compared to healthy controls

SUBMITTER: Wu F 

PROVIDER: S-EPMC12532935 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature