Bioinformatics analysis and in vitro studies identify COX7C as a prognostic predictor in gastric adenocarcinoma.

ABSTRACT:

Background

Stomach adenocarcinoma (STAD) remains a significant threat to human health. This study sought to discover clinically relevant biomarkers for STAD by integrating bioinformatics analysis and in vitro experimental methods.

Methods

We utilized the GSE64951 dataset to screen for differentially expressed genes (DEGs), which were then subjected to weighted gene co-expression network analysis (WGCNA). Candidate modules were subjected to Molecular Complex Detection (MCODE) analysis to extract key genes. Survival analysis and immune infiltration analysis were conducted to identify hub genes associated with STAD prognosis. Among them, cytochrome c oxidase subunit 7 C (COX7C) was selected for further investigation. Its expression levels in normal versus tumor tissues were com

SUBMITTER: Shi C 

PROVIDER: S-EPMC12532943 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature