Molecular insights into the role of desmin intermediate filament network in chromatin landscape, cardiomyocyte differentiation, and maturation.

ABSTRACT: The cardiac cytoskeleton is essential for the proper intracellular and intercellular integration of cardiomyocyte structure, maintenance and function, failure of which leads to cell death and heart disease. In particular, the desmin intermediate filament cytoskeleton, due to its early expression and subcellular distribution, enables the formation of a continuous network that connects the extracellular space with the nuclear matrix, thus allowing us to hypothesize potential key roles in mechanotransduction to the nucleus, and consequently, in cardiac lineage determination, differentiation and development. Here, we investigated the role of desmin in cardiac differentiation and homeostasis across embryogenesis, postnatal life, and adulthood, as well as under various stimuli. Desmin was found

SUBMITTER: Tsikitis M 

PROVIDER: S-EPMC12533021 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature