Application of on-demand aqueous chlorine dioxide solution for non-surgical root canal treatment.

ABSTRACT: Oral biofilms contribute to apical periodontitis, a major cause of tooth loss. This study evaluated the potential of an on-demand aqueous chlorine dioxide solution, "matching transformation system" (MA-T), as a safer alternative to conventional root canal irrigants. The antibacterial activity of MA-T was assessed against mono-species biofilms (Enterococcus faecalis, Parvimonas micra, Fusobacterium nucleatum), polymicrobial biofilms derived from human supragingival plaque, and an in vitro infected root canal model using E. faecalis. Antibacterial efficacy was evaluated using viable cell counting and confocal laser scanning microscopy (CLSM) to quantify the reduction in bacterial load. Biofilm mass was assessed by crystal violet (CV) staining. Cytotoxicity was evaluated by treating rat osteo

SUBMITTER: Shimaoka T 

PROVIDER: S-EPMC12533024 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature