Preparation and evaluation of temozolomide loaded PLGA nanoparticles for the treatment of glioblastoma multiforme.

ABSTRACT: Glioblastoma multiforme (GBM) remains one of the most lethal primary brain tumors, with limited treatment options and poor patient prognosis. Although temozolomide (TMZ) is the standard chemotherapeutic agent for GBM, its clinical efficacy is severely hindered by rapid systemic clearance, low brain penetration, and non-selective cytotoxicity. In this study, we developed and comparatively evaluated two innovative PLGA-based nanoparticle (NP) systems for oral TMZ delivery, prepared via nanoprecipitation and double emulsion solvent evaporation techniques. Comprehensive physicochemical characterization, including particle size, polydispersity index (PDI), zeta potential (ZP), encapsulation efficiency (EE%), in vitro release kinetics, and solid-state analysis (DSC and FTIR), demonstrated the su

SUBMITTER: Sahin S 

PROVIDER: S-EPMC12533060 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature