LASER ablation inductively coupled plasma mass spectrometry enables the recognition of new patterns in metal-related diseases.

ABSTRACT: In this proof-of-concept study, we devised a calibration method with matrix-matched samples (phantoms) and performed quantitative LASER Ablation Inductively Coupled Mass Spectrometry (LA-ICP-MS) on 16 paraffin embedded human liver samples with genetic hemochromatosis (GH) and 5 liver resection specimens with hepatocellular carcinoma arising on GH, with correlation to histology and integration into our lab's workflow. LA-ICP-MS enables easy recognition of histological structures including portal tracts, fibrous septa and centrilobular veins. Compared to adjacent non-tumoral liver, hepatocellular carcinoma presented a decreased iron concentration (p = 0.034) and no significant difference in copper concentration. This profile was similar to that of three Iron Free Foci identified on genetic h

SUBMITTER: Allaume P 

PROVIDER: S-EPMC12533071 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature