Diffusion trajectory of atypical morphological development in autism spectrum disorder.

ABSTRACT: Brain development from childhood through adolescence is crucial for understanding autism spectrum disorder (ASD). Yet how functional networks regulate developmental changes in brain morphology remains unclear. Here, we analyzed gray matter volume (GMV) and functional connectivity (FC) in 301 individuals with ASD and 375 typically developing controls (TDCs), aged 8-18 years, from the Autism Brain Imaging Data Exchange (ABIDE). Using a sliding-window approach, participants were stratified by age, and GMV distribution deviations (DEV) were quantified with Kullback-Leibler divergence and expected value analysis. Network diffusion modeling (NDM) was applied to predict developmental alterations and evaluate how functional networks constrain atypical neurodevelopment. Results revealed a developme

SUBMITTER: Feng Y 

PROVIDER: S-EPMC12533118 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature