Bone regeneration induced by a novel quercetin/a-CSH/n-HA composite in critical size tibia defect of rats with osteoporosis.

ABSTRACT: Bone defects in the presence of osteoporosis present a significant clinical challenge. To address this, we sought to engineer a novel artificial bone substitute exhibiting excellent biocompatibility, osteoconductivity, osteoinduction, anti-aging, and anti-osteoporotic capabilities for enhanced bone regeneration. This project introduces an innovative Q-α-CSH/n-HA composite, synthesized by incorporating Quercetin into alpha-calcium sulfate hemihydrate/nano-hydroxyapatite (α-CSH/n-HA). Q-α-CSH/n-HA composites were fabricated via direct mixing, incorporating Quercetin at concentrations of 0%, 0.5%, 1.5%, and 3%. Physicochemical characteristics were analyzed through Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). The osteoinductive potential and efficacy i

SUBMITTER: Ren M 

PROVIDER: S-EPMC12533126 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature