The regulatory and synergistic effects of FBP2 and HKDC1 on glucose metabolism and malignant progression in gastric cancer.

ABSTRACT: Fructose-1,6-bisphosphatase (FBPase) serves as the rate-limiting enzyme in gluconeogenesis and can be categorized into two subtypes: FBP1 and FBP2. FBP1 has been reported to exhibit reduced expression and impaired function in various malignant tumors. However, there is limited research investigating the role of FBP2 in tumorigenesis. Our results showed that the expression level of FBP2 in gastric cancer (GC) tissues was reduced compared to that in adjacent non-tumor tissues. Low FBP2 expression was correlated with adverse clinicopathological characteristics and unfavorable prognosis. Overexpression of FBP2 in GC cells resulted in a decreased expression level of hypoxia inducible factor-1α (HIF-1α), enhanced oxidative phosphorylation, and a modest reduction in glycolytic activity. Notably,

SUBMITTER: Yu Z 

PROVIDER: S-EPMC12533130 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature