A Mesoporous Calcium Peroxide Nanocuboid with High Tumor Accumulation Across Biological Barriers for High Efficacy Tumor Therapy.

ABSTRACT: The common problem of tumor therapy based on nanoparticles is the limited efficacy due to the blockage of tumor accumulation by biological barriers. To enhance the drug delivery of nanoparticles across biological barriers and augment their tumor accumulation, herein, a mesoporous calcium peroxide nanocuboid (MCPNC) is developed via a facile hydrolysis-precipitation method, which can be utilized for high efficacy tumor therapy by promoting a positive feedback loop of Fenton reaction. The biodistribution results demonstrate that MCPNC exhibits higher accumulation in various tissues than calcium peroxide nanosphere (CPNS). Ferroheme (FH) and exceedingly small magnetic iron oxide nanoparticle (IO) loaded MCPNC is modified with hyaluronic acid (HA), forming MCPNC-FH-IO@HA. Under acidic tumor mi

SUBMITTER: Fan Q 

PROVIDER: S-EPMC12533144 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature