Introducing the University of California, Irvine Corneal Cystine Crystal Score: A Novel Tool for Assessing Corneal Crystal Deposition in Cystinosis Patients.

ABSTRACT: This study aimed to develop and validate the University of California Irvine Corneal Cystine Crystal Score (UCI CCCS), a novel grading system for objectively assessing corneal crystal deposition in cystinosis patients using a slit lamp biomicroscope. This tool provides a standardized method for monitoring disease progression and evaluating treatment efficacy. This retrospective study analyzed clinical records from 36 cystinosis patients examined at the Day of Hope conference, all with the infantile nephropathic form. The records included evaluations from slit-lamp examinations and Best Corrected Visual Acuity (BCVA). After evaluation, the UCI CCCS was developed by experts in pediatric ophthalmology and cornea specialty; this system differentiates cystine crystal density, iris visibility, a

SUBMITTER: Rezaei K 

PROVIDER: S-EPMC12533177 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature