A "3+2" Cooperation Pattern of Amphipathic AIE Phototheranostic System for Multimodal Image-Guided Synergistic Type I/II Photodynamic-Photothermal Therapy.

ABSTRACT: Phototheranostic agents (PTA) control the process of phototheranostics for cancer. However, the existing PTA still cannot meet the needs of practical biomedical applications. Hence the development of new PTA will be imperative. In this contribution, a "3+2" cooperation pattern of amphipathicity PTA (named TDTMSB) with aggregation-induced emission (AIE) features is designed and synthesized to perform near-infrared I/II fluorescence imaging, photoacoustic imaging, photothermal imaging, and Type I/II photodynamic therapy (PDT)-photothermal therapy (PTT) synergistic phototherapy for malignant tumors. Briefly, the target products (TMSB, TTMSB and TDTMSB) are successfully prepared by the reaction of 2-methyl-1-(3-sulfonatepropyl)-benzothiazolium (MSB) and triphenylamine derivatives. They have hi

SUBMITTER: Ma H 

PROVIDER: S-EPMC12533199 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature