Weak and Tunable Adhesion-Clutch Drives Rapid Cell Migration and Glioblastoma Invasion.

ABSTRACT: To move forward, cells must exert backward forces against their surrounding environment. Recent studies have highlighted the importance of integrin-independent forces for cell migration; however, the molecular machinery that exerts forces remains unclear. This study shows that the clutch-linker molecule shootin1 and the cell adhesion molecule L1 transmit the backward force of treadmilling actin filaments to the environment, enabling rapid dendritic cell migration. Notably, shootin1 and L1 transmit weak traction forces, up to ∼100 times weaker than integrin-based forces, by constituting an integrin-independent slippery adhesion-clutch. This adhesion-clutch is tunable in response to the chemoattractant CCL19 and the adhesive ligand laminin, thereby enabling chemotaxis and haptokinesis. Furth

SUBMITTER: Baba K 

PROVIDER: S-EPMC12533206 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature