Genome-wide characterization of lumpy skin disease virus isolate from Bangladesh.

ABSTRACT: This study investigates the genome-wide analysis of the Lumpy Skin Disease Virus (LSDV) isolate from recent outbreaks in Bangladesh. Next-generation sequencing (NGS) revealed high sequence conservation with minor mutations and structural variations. Phylogenetic and genomic diversity assessments revealed 99.9% concordance, and identified several point mutations and small indels that contribute to strain-specific variability. The study identifies 156 unique protein-coding sequences, with 71.8% classified as soluble and 28.2% as membrane-associated proteins, shedding light on functional diversity. Repeat analysis highlights a predominance of short tandem repeats (10-30 bp) and low copy numbers (2-3), low entropy (0.39), and high thymine content (92%), suggesting selection for compact, stable

SUBMITTER: Uddin MB 

PROVIDER: S-EPMC12533222 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature