Impact of neoadjuvant and adjuvant chemotherapy on breast cancer prognosis in a propensity score matched population.

ABSTRACT: Breast cancer is the most common cancer among women worldwide. To evaluate the real-world effectiveness of Neo-adjuvant chemotherapy (NACT) and adjuvant chemotherapy (ACT), we conducted a retrospective study comparing their impact on breast cancer prognosis. We retrieved data from the SEER database. We applied propensity score matching (PSM) to minimize confounding factors. Breast-cancer specific survival (BCSS) and overall survival (OS) were compared between the two groups. We also developed a nomogram prognostic model using clinicopathological parameters to predict survival rates. We identified 46,447 eligible patients in the SEER database. After PSM, 9,025 patients were included in each group, with 11,762 patients receiving NACT and 34,685 undergoing ACT before PSM. In the PSM cohort, t

SUBMITTER: Xu Y 

PROVIDER: S-EPMC12533238 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature