Temporal Trends in Red Blood Cell and Platelet Transfusion Thresholds for Extremely Low Birth Weight Infants.

ABSTRACT:

Objective

To evaluate if hematologic thresholds for red blood cell (RBC) and platelet transfusions changed over time following publication of new evidence from randomized trials in a multicenter cohort of extremely low birth weight (ELBW) infants.

Study design

We analyzed data from the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study-IV-Pediatrics study from April 2019 through December 2023. We compared pretransfusion hemoglobin and platelet counts closest to each transfusion within 24 hours by year using linear mixed models and used model interaction terms to determine if trends over time differed by postnatal weeks.

Results

We evaluated 981 ELBW infants. For trends in RBC transfusion thresholds, 785 infants (80%) received 518

SUBMITTER: Patel RM 

PROVIDER: S-EPMC12533266 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature