Plasma Metabolic Profile with Machine Learning Reveals Distinct Diagnostic and Biological Signatures for Pathologic Myopia.

ABSTRACT: Pathologic myopia (PM), characterized by serious myopic macular degeneration (MMD), is a detrimental subtype of high myopia (HM) and has become one of the leading causes of blindness worldwide. In this concern, precise and high-throughput molecular diagnosis and further pathologic insights are urgently needed. Here, through the combined strategy of nanoparticle-enhanced laser desorption/ionization mass spectrometry-based rapid metabolic analysis (<30 s) and machine learning, a precise molecular diagnostic approach of PM (HM with MMD grade ≥ 2) is proposed, which achieves areas under the curve of 0.874 and 0.889 for diagnosing PM and early-stage PM, respectively. Further, the biomarkers indicate the PM-associated systemic metabolic reprogramming of amino acid and lipid metabolism, which may

SUBMITTER: Qi Z 

PROVIDER: S-EPMC12533321 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature