SPAmix: a scalable, accurate, and universal analysis framework for large-scale genetic association studies in admixed populations.

ABSTRACT:

Background

Inclusion of individuals with diverse or admixed genetic ancestries is crucial to discover novel findings that may be missed by genomics analyses rooted solely in European population.

Results

Here, we present an analysis framework, SPAmix, which is scalable to a large-scale biobank data analysis including hundreds of thousands of admixed individuals and is universally applicable to various types of complex traits including quantitative traits, time-to-event traits, ordinal traits, and longitudinal traits. Since no alternative model is fitted, SPAmix primarily focuses on association p values. For each genetic variant, SPAmix uses genotype data and genetic principal components to estimate individual-specific allele frequency, which is subsequently used to calibrate

SUBMITTER: Ma Y 

PROVIDER: S-EPMC12533355 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature