Osteoblast-CD4⁺ CTL Crosstalk Mediated by SIRT1/DAAM2 Axis Prevents Age-Related Bone Loss.

ABSTRACT: The dynamic production and clearance of senescent osteoblasts affects bone homeostasis and health. However, the relationship between senescent osteoblasts and the immune system remains unclear. Here, a landscape of the interaction between immune cells and osteoblasts through spatial analysis of the bone microenvironment is presented. Sirtuin 1 (SIRT1), a longevity gene, regulates bone mass maintenance through a mechanism involving osteoblast-CD4⁺ cytotoxic T lymphocyte (CTL) crosstalk. In the osteoblastic niche, SIRT1 promotes the secretion of crucial chemokines, such as C-C motif chemokine ligand 3 (CCL3), C-C motif chemokine ligand 5 (CCL5), and C-X-C motif chemokine ligand 10 (CXCL10), by upregulating dishevelled-associated activator of morphogenesis 2 (DAAM2) through the ace

SUBMITTER: Yang B 

PROVIDER: S-EPMC12533366 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature