Magnetic Fe₃O₄ Nanoparticles Modified Hydroxyapatite Whisker: A Novel Framework with Superior Osteogenic Efficacy.

ABSTRACT: The valid repair of bone defects requires considering precise elements mirroring native tissue and the efficiency of treatment reality. Magnetic biomaterial-mediated mechanotransduction emerges as a critical mechanism for enhancing osteogenic differentiation and bone regeneration. Here, enhancement of osteogenic capacity is achieved in a hydroxyapatite whisker (HAw) by integrating with magnetic Fe₃O₄ nanoparticles (HAw/Fe₃O₄). The HAw/Fe₃O₄ exhibited excellent magnetic responsiveness and controllable alignment along magnetic field (MF) vectors enabled precise delivery of programmed mechanical stimuli. In vitro and in vivo experiments showed that Fe₃O₄ nanoparticles modified HAw has satisfactory biocompa

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12533391 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature