Exploring the Causal Relationships and Mediating Factors Between Mental Disorders and Hypertension: A Multivariable Mendelian Randomization Study.

ABSTRACT:

Background

Previous studies have demonstrated a correlation between mental disorders and hypertension. However, the direction of this association and the specific risk factors that mediate the causal effects remain unknown. The present study aimed to investigate the causal relationship between mental disorders and hypertension, as well as identify the risk factors that mediate it.

Methods

We used univariate Mendelian randomization (UVMR) and multivariate Mendelian randomization (MVMR) to evaluate the causal relationship between depression, anxiety, or panic attacks and hypertension using the summarized statistics from eleven extensive genome-wide association studies in European populations. Furthermore, MVMR was used to evaluate seven potential mediators of this association

SUBMITTER: Li K 

PROVIDER: S-EPMC12533420 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature