Clinical significance and expression of ALDH1 in triple-negative breast cancer.

ABSTRACT:

Background

Triple-negative breast cancer (TNBC) is aggressive and has limited therapeutic options due to the absence of targeted therapies, highlighting the urgent need for prognostic biomarkers linked to cancer stemness and chemoresistance. Aldehyde dehydrogenase 1 (ALDH1), a key regulator of stem cell properties, remains incompletely characterized in TNBC clinical cohorts.

Methods

ALDH1 mRNA expression levels were analyzed using the GEO2R online database, and its prognostic significance was assessed via the Kaplan‒Meier plotter tool. Immunohistochemical (IHC) staining was performed on a tissue microarray comprising 96 TNBC samples and paired adjacent normal tissues from patients treated at Binzhou People's Hospital between 2016 and 2022. The associations between ALDH1 expr

SUBMITTER: Yang Y 

PROVIDER: S-EPMC12533427 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature