Fe-doped phase-transition nanodroplets for synergistic photothermal and starvation-enhanced ferroptosis in cancer therapy.

ABSTRACT:

Background

Ferroptosis therapy has emerged as a promising antitumor strategy by utilizing the Fenton reaction to destroy cancer cells, where Fe²⁺ catalyzes the decomposition of H₂O₂ into hydroxyl radicals (•OH). Despite the great potential of ferroptosis therapy in suppressing tumor growth, inadequate catalysts and reactants within tumors remains a major challenge before its clinical translation. Herein, we developed glucose oxidase (GOx)-loaded phase-transition nanodroplets (PND) modified with Fe-tannic acid (TA) networks (PND@GOx@Fe-TA) for enhanced antitumor efficacy of ferroptosis therapy via synergistic photothermal and starvation therapy.

Results

PND@GOx@Fe-TA can convert glucose into H₂O₂, which not only provides

SUBMITTER: Tian Y 

PROVIDER: S-EPMC12533436 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature