Causal effects and mediation pathways of circulating plasma proteins on osteoporosis: a two-sample and two-step Mendelian randomization study.

ABSTRACT: This study, using a two-sample and two-step Mendelian randomization (MR) approach, reveals a causal relationship between specific circulating plasma proteins and osteoporosis risk, and further identifies key deCODE Genetics plasma proteins (measured in a different population and using an independent proteomic platform) mediating the effects of upstream UKB plasma proteins.Notably, proteins such as NT5C, GREM1, BOLA1, and CCL19 were found to partially mediate the effects of upstream UKB plasma proteins on bone health. These findings shed light on a multi-tiered protein regulatory network underlying osteoporosis and provide potential targets for therapeutic intervention.

Introduction

Osteoporosis is a multifactorial skeletal disorder characterized by reduced bone mineral density (BMD)

SUBMITTER: Wang H 

PROVIDER: S-EPMC12533449 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature