Genetically Predicted Immunocyte Phenotypes as Risk and Protective Factors in Glaucoma: An Exploratory Bidirectional Mendelian Randomization Study.

ABSTRACT:

Purpose

Glaucoma is characterized by progressive retinal ganglion cell loss and irreversible sight damage and is reported to be interacting with immunological dysregulation. Primary open-angle glaucoma (POAG) and primary angle-closure glaucoma (PACG) are two of the most frequent subtypes. This study aimed to explore the associations between the immune system and glaucoma by investigating the causal relationships between POAG or PACG and immunocyte phenotypes.

Methods

A two-sample Mendelian randomization (MR) approach was carried out to comprehensively analyze the genetic variants associated 731 immunocyte phenotypes and their influence on glaucoma outcomes. Data were obtained from genome-wide association studies and the FinnGen consortium, with rigorous statistical methods a

SUBMITTER: Hong Y 

PROVIDER: S-EPMC12533510 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature