Biophysically constrained dynamical modelling of the brain using multimodal magnetic resonance imaging.

ABSTRACT: We propose a Biophysically Restrained Analog Integrated Neural Network (BRAINN), an analog electrical network that models the dynamics of brain function. The network interconnects analog electrical circuits that simulate two tightly coupled brain processes: (1) propagation of an action potential, and (2) regional cerebral blood flow in response to the metabolic demands of signal propagation. These two processes are modeled by two branches of an electrical circuit comprising a resistor, a capacitor, and an inductor. We estimated the electrical components from in vivo multimodal MRI together with the biophysical properties of the brain applied to state-space equations, reducing arbitrary parameters such that the dynamic behavior is determined by neuronal integrity. Electrical circuits were i

SUBMITTER: Bansal S 

PROVIDER: S-EPMC12533546 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature