Metabolite Profiles of Heart Failure, Central Hemodynamic Derangement, and Response to Heart Transplantation.

ABSTRACT:

Background

Heart failure (HF) is characterized by hemodynamic derangements that are likely to mediate systemic metabolic perturbations but limited data are available. Plasma metabolite profiling provides opportunities for comprehensive investigation of such perturbations. Here, we aimed to characterize plasma profiles that associate with HF and their relationship with central hemodynamics, symptom burden, and response to restoration of cardiac function by heart transplantation.

Methods

Untargeted metabolite profiling was conducted with mass spectrometry in 2 independent case-control samples.

Results

In total, 89 of 797 studied metabolites were significantly associated with HF in both cohorts with concordant directionality. Amino acid, carbohydrate, and nucleotide meta

SUBMITTER: Lejonberg C 

PROVIDER: S-EPMC12533607 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature