Early Aortic Valve Replacement of Asymptomatic Severe Aortic Stenosis: A Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Background

Asymptomatic severe aortic stenosis may lead to the progression to both symptoms and adverse outcomes if left untreated. The appropriate timing of intervention for these patients remains controversial, and any decision requires careful assessment.

Methods

We searched PubMed, Web of Science, EMBASE, and Cochrane Library for randomized controlled trials comparing early aortic valve replacement with conservative management in asymptomatic patients with severe aortic stenosis until December 2024. The primary efficacy outcome was a composite of all-cause mortality, hospitalization for cardiovascular causes, stroke, and myocardial infarction. We expressed outcome data as risk ratios (RRs) with 95% CIs.

Results

We included 4 randomized controlled trials involving

SUBMITTER: Song Q 

PROVIDER: S-EPMC12533610 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature