Exploring the Impact of Urinary Metal Exposure on Blood Lipid Profiles in Chinese Adults: Mediating Roles of Health-Related Indicators.

ABSTRACT:

Background

The relationship between urinary metal exposure and lipid profiles remains unclear, particularly regarding potential mediators. This study aimed to investigate associations between urinary metals and lipid levels and to explore mediating health indicators.

Methods

We included 14 817 participants in the CMEC (Chinese Multi-Ethnic Cohort) study baseline data. Twenty-one urinary metals, 16 health indicators, and lipid profiles were measured to explore their relationships.

Results

In single-metal models, each unit increase in urinary zinc was associated with higher total cholesterol by 12%, triglycerides by 29%, and low-density lipoprotein cholesterol by 14%, along with lower high-density lipoprotein cholesterol by 3%, and increased odds of dyslipidemia (odds r

SUBMITTER: Zhong J 

PROVIDER: S-EPMC12533618 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature