Adventitial Fibroblasts Release Interleukin 6 After Vascular Injury and Induce Smooth Muscle Cell Proliferation and Neointima Formation.

ABSTRACT:

Background

Vascular restenosis resulting from neointima formation significantly limits the efficacy of percutaneous interventional therapies compared with bypass surgery. The adventitial layer is involved in neointima formation, but the detailed pathophysiological interplay of the different cell types in this process is still unclear.

Methods

We analyzed the correlation between adventitial and neointimal tissue size in human postmortem restenotic lesions after angioplasty. In porcine and mouse models of vascular injury, we examined early proliferation of fibroblasts and adventitial expansion. Using anti-CD45 antibodies, we identified recruited leukocytes as the source of fibroblast activation following vascular injury in mice. A time-course experiment on neointima formation

SUBMITTER: Dutzmann J 

PROVIDER: S-EPMC12533623 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature