Risk of Poststroke Dementia in Patients With and Without Atrial Fibrillation: A Nationwide Cohort Study.

ABSTRACT:

Background

Atrial fibrillation (AF) is associated with an increased risk of dementia in nonstroke populations. We aimed to study whether AF was also associated with an increased risk of poststroke dementia (PSD).

Methods

This nationwide register-based cohort study included all patients with incident acute ischemic stroke (AIS) in Denmark from 2008 to 2017. Patients with AF were compared with patients without AF using propensity-score weighting. The primary outcome was PSD, determined as a diagnosis of dementia or use of dementia medication within 5 years from AIS. PSD hazard rates were compared between patients with and without AF using Cox proportional hazards regression. Dementia-free mortality risk was evaluated as a secondary outcome.

Results

We included 61 058 pa

SUBMITTER: Vestergaard SB 

PROVIDER: S-EPMC12533633 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature