ELABELA Ameliorates Atherosclerosis Through Restoring the M1/M2 Macrophage Balance in <i>ApoE</i>^-/- Mice.

ABSTRACT:

Background

Atherosclerosis is a progressive arterial disease characterized by chronic inflammation and plaque formation in blood vessel walls. ELABELA, an endogenous ligand for the G protein-coupled receptor APJ (apelin peptide jejunum, apelin receptor), has multiple pharmacological activities for protecting the cardiovascular system. This study aimed to determine the potential antiatherosclerotic effect of ELABELA and reveal the underlying mechanisms.

Methods

We enrolled a cohort consisting of patients with and without atherosclerosis to determine the relationship between plasma ELABELA levels and atherosclerosis severity. The potential therapeutic action of ELA-21 (ELABELA-21) on atherosclerosis in high-fat diet-fed ApoE^-/- mice was evaluated.

Results<

SUBMITTER: Tang L 

PROVIDER: S-EPMC12533657 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature