IDO-1 Promotes Pulmonary Vascular Remodeling Via Kynurenine Pathway in Pulmonary Arterial Hypertension.

ABSTRACT:

Background

Activation of the plasma kynurenine pathway (KP) may contribute to the progression of pulmonary arterial hypertension (PAH). We investigated the functional role and molecular mechanisms of KP activation in PAH.

Methods

KP activity was measured in the lungs and plasma of humans and rodents with pulmonary hypertension (PH). KP activity was modulated in lung microvascular endothelial cells in vitro, and through daily oral administration of epacadostat, an inhibitor of IDO-1 (indoleamine 2,3-dioxygenase), the rate-limiting enzyme of the KP, in rats with monocrotaline-induced PH.

Results

IDO-1 expression was increased in peripheral blood mononuclear cells but not in lung tissue of patients with PAH and in rats with monocrotaline-induced PH. Epacadostat prevented

SUBMITTER: Cai Z 

PROVIDER: S-EPMC12533658 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature