Invasive Versus Conservative Management Among Older Adult Patients With Non-ST-Segment-Elevation Myocardial Infarction: A Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Background

Older adult patients have been underrepresented in the pivotal trials comparing an invasive versus conservative management for non-ST-segment-elevation myocardial infarction (NSTEMI).

Methods

We performed an electronic search of MEDLINE, Embase, and Cochrane databases through September 2024 for randomized controlled trials comparing invasive versus conservative management of NSTEMI in patients aged ≥70 years.

Results

The final analysis included 7 randomized controlled trials with 2997 patients. The weighted mean follow-up time was 47.1 months, and the mean age was 82.6 years. There was no significant difference in all-cause mortality between an invasive versus a conservative management approach (27.9% versus 26.6%; risk ratio [RR], 1.05 [95% CI, 0.94-1.18];

SUBMITTER: Hamed M 

PROVIDER: S-EPMC12533662 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature