Risk of Acute Infections in New Users of Antihypertensive Drugs: An Observational Cohort Study.

ABSTRACT:

Background

Functional inhibitors of acid sphingomyelinase enhance human immune function in vitro. We compared the risk of acute infection in users of amlodipine, a functional inhibitor of acid sphingomyelinase, to users of other first-line antihypertensive drugs.

Methods

We conducted a cohort study using the UK Clinical Practice Research Datalink GOLD (2000-2021). We included new monousers of amlodipine, ramipril, or bendroflumethiazide without preexisting cardiovascular disease. In 2 pairwise comparisons (amlodipine versus ramipril/bendroflumethiazide), we followed patients for as long as they were exposed to compare risk of the primary outcome (acute outpatient infections including respiratory, genitourinary, gastrointestinal infections, and sepsis) and diagnosed SARS-CoV-

SUBMITTER: Aebi N 

PROVIDER: S-EPMC12533667 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature