KAT2A-H3K79succ-Mediated SH2B3 Upregulation Promotes TNBC Metastasis Through Diminishing the Ubiquitin-Dependent Degradation of Vimentin.

ABSTRACT: Triple-negative breast cancer (TNBC) is the most aggressive subtype among all breast cancer subtypes, attributed to the paucity of available targeted therapeutics. Lysine acetyltransferase 2A (KAT2A), an indispensable catalytic constituent of the transcriptional regulatory complex, has been implicated in the pathogenesis and progression of multiple malignancies. Nevertheless, the role of H3K79 site succinylation (H3K79succ) catalyzed by KAT2A in TNBC remains enigmatic. This study assessed the functional role of KAT2A in TNBC pathogenesis through colony formation assays, CCK-8 assay, wound healing assays, and transwell invasion assays. BALB/c nude mice were employed to establish models for studying the proliferation and metastasis of TNBC in vivo. Transcriptome sequencing (RNA-seq) combined

SUBMITTER: Shi X 

PROVIDER: S-EPMC12533684 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature