Atrial Mechanics in Heart Failure With Preserved Ejection Fraction: Effect of a No-Implant Interatrial Shunt.

ABSTRACT:

Background

The atria play an important role in the pathophysiology of heart failure with preserved ejection fraction. Decreased left atrial strain is associated with worse clinical outcomes. The impact of no-implant interatrial shunting on atrial structure and function has not been described.

Methods

We characterized the left atrial (LA) and right atrial strain-pressure relationship at rest and during exercise, before and after creation of a no-implant interatrial shunt. We included patients with New York Heart Association class II, III, or ambulatory IV heart failure with a left ventricular ejection fraction ≥40% and elevated LA wedge pressure during supine ergometry (≥25 mm Hg). Exercise hemodynamics and echocardiographic measurements were analyzed at baseline, 1 month and

SUBMITTER: Laufer-Perl M 

PROVIDER: S-EPMC12533783 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature