Coordination of the Fe-S cluster biogenesis network by the sRNA RyhB in <i>E. coli</i>.

ABSTRACT: Iron (Fe) plays critical roles as enzyme cofactor involved in key biological processes but can also lead to toxicity by catalysing the formation of highly damaging reactive oxygen species. To stabilize Fe and perform catalysis, most organisms rely on Fe-S clusters, which are fundamental and evolutionary ancient cofactors. In E. coli, two distinct pathways for the biosynthesis of Fe-S cluster exist: the three-part iscR-SUA-hscBA-fdx-iscX (ISC-HSC) operon and the sufABCDSE (SUF) operon. The iscR-SUA section of the ISC-HSC operon is regulated at the promoter level by the IscR transcription factor and post-transcriptionally by the small RNA (sRNA) RyhB. The SUF operon is regulated by a combination of transcription factors, including the Fe-sensing Fur, the Fe-S usin

SUBMITTER: Prevost K 

PROVIDER: S-EPMC12533949 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature