Differential equation modeling of cell population dynamics in skeletal muscle regeneration from single-cell transcriptomic data.

ABSTRACT: Skeletal muscle regeneration is a complex process orchestrated by diverse cell populations within a dynamic niche. In response to muscle damage and intercellular signaling, these cells undergo cell fate and migration decisions including quiescence, activation, proliferation, differentiation, infiltration, apoptosis, and exfiltration. The emergence of single-cell RNA sequencing (scRNA-seq) studies of muscle regeneration offers a significant opportunity to refine models of regeneration and enhance our understanding of cellular interactions. To better understand how crosstalk between cell types governs cell fate decisions and cell population dynamics, we developed a novel non-linear ordinary differential equation model guided by scRNA-seq data. Our model consists of 9 variables and 17 paramet

SUBMITTER: Al-Ghazawi R 

PROVIDER: S-EPMC12533972 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature