Understanding thromboembolus transport patterns in the brain for stroke in the presence of carotid artery stenosis.

ABSTRACT: Deciphering the source of an embolism is a common challenge encountered in stroke treatment. Carotid stenosis is a key source of embolic strokes. Carotid interventions can be indicated when a patient has greater than 50% stenosis in the carotid ipsilateral to the cerebral infarction, which is designated as the symptomatic carotid. However, there are often a significant number of cases where carotid emboli travel contralaterally, leading to ambiguity regarding which carotid is symptomatic. We use a patient-specific computational embolus-hemodynamics interaction model developed in prior works to conduct an in silico experiment spanning 30 heart-to-brain arterial models with differing combinations of bilateral severe and mild stenosis degrees. We used these models to study source-to-destinati

SUBMITTER: Roopnarinesingh R 

PROVIDER: S-EPMC12533973 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature