A compact model of Escherichia coli core and biosynthetic metabolism.

ABSTRACT: Metabolic models condense biochemical knowledge about organisms in a structured and standardised way. As large-scale network reconstructions are readily available for many organisms, genome-scale models are being widely used among modellers and engineers. However, these large models can be difficult to analyse and visualise, and occasionally generate predictions that are hard to interpret or even biologically unrealistic. Of the thousands of enzymatic reactions in a typical bacterial metabolism, only a few hundred form the metabolic pathways essential to produce energy carriers and biosynthetic precursors. These pathways carry relatively high flux, are central to maintaining and reproducing the cell, and provide precursors and energy to engineered metabolic pathways. Focusing on these cent

SUBMITTER: Corrao M 

PROVIDER: S-EPMC12533975 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature