Identifying occult high-risk features and stratified management strategies following curative resection for ampullary adenocarcinoma.

ABSTRACT:

Objective

The aim of the current study was to identify independent prognostic factors, evaluate differential adjuvant chemotherapy efficacy across clinicopathologic subgroups, and define adjuvant chemotherapy-sensitive populations.

Methods

A retrospective analysis of 168 AAC patients undergoing curative pancreaticoduodenectomy (2011-2020) was performed. Cases were classified into intestinal (28.0%), pancreatobiliary (30.4%), and mixed subtypes (18.5%) per NCCN (v2.2025) criteria. Independent prognostic factors for AAC patients were identified through uni- and multi-variable Cox proportional hazards modeling and subgroup analyses were stratified by age range, gender, differentiation, T stage, N stage, BVI, TDs, and PNI.

Results

The pancreatobiliary signature (HR = 2.88

SUBMITTER: Ma X 

PROVIDER: S-EPMC12533976 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature